Modulation of P2X4 receptor activity by ivermectin and 5‐BDBD has no effect on the development of ARPKD in PCK rats

Abstract Autosomal recessive polycystic kidney disease (ARPKD) is an inherited pathology caused mainly by mutations of the polycystic kidney and hepatic disease 1 (PKHD1) gene, which usually leads to end‐stage renal disease. Previous studies suggested that the P2X purinoreceptor 4 (P2X4R) may play a...

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Bibliographic Details
Main Authors: Biyang Xu, Oksana Nikolaienko, Vladislav Levchenko, Apurva Swapnil Choubey, Elena Isaeva, Alexander Staruschenko, Oleg Palygin
Format: Article
Language:English
Published: Wiley 2022-11-01
Series:Physiological Reports
Subjects:
Online Access:https://doi.org/10.14814/phy2.15510