Design, Synthesis and Assay of Novel Methylxanthine–Alkynylmethylamine Derivatives as Acetylcholinesterase Inhibitors

Design, Synthesis and Assay of Novel Methylxanthine–Alkynylmethylamine Derivatives as Acetylcholinesterase Inhibitors

Xanthine derivatives have been a great area of interest for the development of potent bioactive agents. Thirty-eight methylxanthine derivatives as acetylcholinesterase inhibitors (AChE) were designed and synthesized. Suzuki–Miyaura cross-coupling reactions of 8-chlorocaffeine with aryl(hetaryl)boron...

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Bibliographic Details
Main Authors: Danila V. Reshetnikov, Igor D. Ivanov, Dmitry S. Baev, Tatyana V. Rybalova, Evgenii S. Mozhaitsev, Sergey S. Patrushev, Valentin A. Vavilin, Tatyana G. Tolstikova, Elvira E. Shults
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
methylxanthines
caffeine
theophylline
theobromine
A<sup>3</sup>-coupling reactions
acetylcholinesterase inhibitor
Online Access:https://www.mdpi.com/1420-3049/27/24/8787

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https://www.mdpi.com/1420-3049/27/24/8787

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