Impact of extended-release niacin on immune activation in HIV-infected immunological non-responders on effective antiretroviral therapy

Impact of extended-release niacin on immune activation in HIV-infected immunological non-responders on effective antiretroviral therapy

Background Background: Tryptophan (Trp) catabolism into immunosuppressive kynurenine (Kyn) is involved in immune dysregulation during HIV infection. Niacin (vitamin B3) could control the excess of tryptophan depletion and represents a potential strategy to improve immune functions and CD4 count reco...

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Main Authors: Bertrand Lebouché, Alexis Yero, Tao Shi, Omar Farnos, Joel Singer, Ido Kema, Cecilia T. Costiniuk, Réjean Thomas, Marie-Josée Brouillette, Kim Engler, Jean-Pierre Routy, Mohammad-Ali Jenabian, for the CTN PT006 Study Group
Format: Article
Language:English
Published: Taylor & Francis Group 2020-12-01
Series:HIV Research & Clinical Practice
Subjects:
hiv
niacin
tryptophan
kynurenine
ido
immune activation
inflammation
immunological non-responders
Online Access:http://dx.doi.org/10.1080/25787489.2020.1866846

Internet

http://dx.doi.org/10.1080/25787489.2020.1866846

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