DDX4 enhances antiviral activity of type I interferon by disrupting interaction of USP7/SOCS1 and promoting degradation of SOCS1

DDX4 enhances antiviral activity of type I interferon by disrupting interaction of USP7/SOCS1 and promoting degradation of SOCS1

ABSTRACTDEAD-box helicase (DDX) family members play differential roles in regulating innate antiviral immune response. However, the physiological roles played by DDX4 in antiviral innate immunity remain unclear. In this study, we unveiled that DDX4 acts as a positive regulatory molecule of Type-I in...

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Bibliographic Details
Main Authors: Ying Miao, Tingting Zhang, Mingcheng Guan, Qian Zhao, Renxia Zhang, Xuyi Liu, Tianrun Ma, Tengfei Ren, Zhijin Zheng, Wei He, Wanying Tian, Qun Cui, Xingyu Zhai, Yibo Zuo, Hong Zhu, Hui Zheng, Yukang Yuan
Format: Article
Language:English
Published: American Society for Microbiology 2024-03-01
Series:mBio
Subjects:
antiviral activity
interferon
DEAD-box helicase 4
suppressor of cytokine signaling 1
ubiquitin-specific protease 7
Online Access:https://journals.asm.org/doi/10.1128/mbio.03213-23

Internet

https://journals.asm.org/doi/10.1128/mbio.03213-23

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