A novel chemical attack on Notch-mediated transcription by targeting the NACK ATPase

A novel chemical attack on Notch-mediated transcription by targeting the NACK ATPase

Notch activation complex kinase (NACK) is a component of the Notch transcriptional machinery critical for the Notch-mediated tumorigenesis. However, the mechanism through which NACK regulates Notch-mediated transcription is not well understood. Here, we demonstrate that NACK binds and hydrolyzes ATP...

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Bibliographic Details
Main Authors: Giulia Diluvio, Tanya T. Kelley, Mohini Lahiry, Annamil Alvarez-Trotta, Ellen M. Kolb, Elena Shersher, Luisana Astudillo, Rhett A. Kovall, Stephan C. Schürer, Anthony J. Capobianco
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
small-molecule inhibitor
ATPase
Notch signaling
pseudokinase
SGK223
esophageal adenocarcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770523000165

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http://www.sciencedirect.com/science/article/pii/S2372770523000165

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