Synergistic efficacy of PI3Kδ inhibitor with anti-PD-1 mAbs in immune-humanized PDX model of endocrine resistance hormone receptor-positive advanced breast cancer

Synergistic efficacy of PI3Kδ inhibitor with anti-PD-1 mAbs in immune-humanized PDX model of endocrine resistance hormone receptor-positive advanced breast cancer

Purpose: Endocrine resistance hormone receptor-positive (HR+) advanced breast cancer (ABC) is generally insensitive to immunecheckpoint inhibitors (ICIs). This study sought to determine whether PI3Kδ inhibitor could enhance the sensitivity of endocrine resistance HR + advanced BC to ICIs by reducing...

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Bibliographic Details
Main Authors: Yingjue Li, Yiwen Li, Yu Yang, Yuwei Deng, Xiangdong Ni, Bochen Zhao, Zhaoqi Yan, Wen He, Yixin Li, Shuhui Li, Linbo Liu, Dan Lu
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Heliyon
Subjects:
Breast cancer (BC)
Patient-derived xenograft
Immune checkpoint inhibitors
PI3Kδ inhibitor
Endocrine therapy resistance
Humanized mice
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023057067

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http://www.sciencedirect.com/science/article/pii/S2405844023057067

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