RfaH Counter-Silences Inhibition of Transcript Elongation by H-NS–StpA Nucleoprotein Filaments in Pathogenic Escherichia coli

RfaH Counter-Silences Inhibition of Transcript Elongation by H-NS–StpA Nucleoprotein Filaments in Pathogenic Escherichia coli

ABSTRACT Expression of virulence genes in pathogenic Escherichia coli is controlled in part by the transcription silencer H-NS and its paralogs (e.g., StpA), which sequester DNA in multi-kb nucleoprotein filaments to inhibit transcription initiation, elongation, or both. Some activators counter-sile...

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Bibliographic Details
Main Authors: Christine M. Hustmyer, Michael B. Wolfe, Rodney A. Welch, Robert Landick
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:mBio
Subjects:
bacterial chromatin
ChIP-seq
counter-silencing
gene silencing
H-NS
RNAP
Online Access:https://journals.asm.org/doi/10.1128/mbio.02662-22

Internet

https://journals.asm.org/doi/10.1128/mbio.02662-22

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