Stability of XIST repression in relation to genomic imprinting following global genome demethylation in a human cell line

Stability of XIST repression in relation to genomic imprinting following global genome demethylation in a human cell line

DNA methylation is essential in X chromosome inactivation and genomic imprinting, maintaining repression of XIST in the active X chromosome and monoallelic repression of imprinted genes. Disruption of the DNA methyltransferase genes DNMT1 and DNMT3B in the HCT116 cell line (DKO cells) leads to globa...

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Bibliographic Details
Main Authors: E.S.S. de Araújo, L.R. Vasques, R. Stabellini, A.C.V. Krepischi, L.V. Pereira
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2014-12-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
XIST
Imprinted genes
DNA methylation
5-aza-2′-deoxycytidine
Human cell line
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001201029&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001201029&lng=en&tlng=en

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