COP1 and GSK3β Cooperate to Promote c-Jun Degradation and Inhibit Breast Cancer Cell Tumorigenesis

COP1 and GSK3β Cooperate to Promote c-Jun Degradation and Inhibit Breast Cancer Cell Tumorigenesis

High abundance of c-Jun is detected in invasive breast cancer cells and aggressive breast tumor malignancies. Here, we demonstrate that a major cause of high c-Jun abundance in invasive breast cancer cells is prolonged c-Jun protein stability owing to poor poly-ubiquitination of c-Jun. Among the kno...

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Bibliographic Details
Main Authors: Jing Shao, Yong Teng, Ravi Padia, Sungguan Hong, Hyangsoon Noh, Xiayang Xie, Jeff S. Mumm, Zheng Dong, Han-Fei Ding, John Cowell, Jaejik Kim, Jiahuai Han, Shuang Huang
Format: Article
Language:English
Published: Elsevier 2013-09-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558613800188

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http://www.sciencedirect.com/science/article/pii/S1476558613800188

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