The critical role of ferritinophagy in human disease

The critical role of ferritinophagy in human disease

Ferritinophagy is a type of autophagy mediated by nuclear receptor activator 4 (NCOA4), which plays a role in inducing ferroptosis by regulating iron homeostasis and producing reactive oxygen species in cells. Under physiological conditions, ferritinophagy maintains the stability of intracellular ir...

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Bibliographic Details
Main Authors: Meng-Zhen Liu, Ni Kong, Guang-Yu Zhang, Qin Xu, Yang Xu, Ping Ke, Chong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
ferroptosis
ferritinophagy
iron homeostasis
NCOA4
heme degradation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.933732/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.933732/full

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