Vaccination with DNA plasmids expressing Gn coupled to C3d or alphavirus replicons expressing gn protects mice against Rift Valley fever virus.

Vaccination with DNA plasmids expressing Gn coupled to C3d or alphavirus replicons expressing gn protects mice against Rift Valley fever virus.

Rift Valley fever (RVF) is an arthropod-borne viral zoonosis. Rift Valley fever virus (RVFV) is an important biological threat with the potential to spread to new susceptible areas. In addition, it is a potential biowarfare agent.We developed two potential vaccines, DNA plasmids and alphavirus repli...

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Bibliographic Details
Main Authors: Nitin Bhardwaj, Mark T Heise, Ted M Ross
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC2889828?pdf=render

Internet

http://europepmc.org/articles/PMC2889828?pdf=render

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