Intratumoral electroporation of a self-amplifying RNA expressing IL-12 induces antitumor effects in mouse models of cancer

Intratumoral electroporation of a self-amplifying RNA expressing IL-12 induces antitumor effects in mouse models of cancer

Alphavirus vectors based on self-amplifying RNA (saRNA) generate high and transient levels of transgene expression and induce innate immune responses, making them an interesting tool for antitumor therapy. These vectors are usually delivered as viral particles, but it is also possible to administer...

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Bibliographic Details
Main Authors: Noelia Silva-Pilipich, Aritz Lasarte-Cía, Teresa Lozano, Celia Martín-Otal, Juan José Lasarte, Cristian Smerdou
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
self-amplifying RNA
Semliki Forest virus
in vivo electroporation
cancer gene therapy
interleukin-12
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122001895

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http://www.sciencedirect.com/science/article/pii/S2162253122001895

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