Large-scale filament formation inhibits the activity of CTP synthetase

Large-scale filament formation inhibits the activity of CTP synthetase

CTP Synthetase (CtpS) is a universally conserved and essential metabolic enzyme. While many enzymes form small oligomers, CtpS forms large-scale filamentous structures of unknown function in prokaryotes and eukaryotes. By simultaneously monitoring CtpS polymerization and enzymatic activity, we show...

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Bibliographic Details
Main Authors: Rachael M Barry, Anne-Florence Bitbol, Alexander Lorestani, Emeric J Charles, Chris H Habrian, Jesse M Hansen, Hsin-Jung Li, Enoch P Baldwin, Ned S Wingreen, Justin M Kollman, Zemer Gitai
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-07-01
Series:eLife
Subjects:
CTP synthetase
nucelotide metabolism
pyrimidine metabolism
enzyme regulation
Online Access:https://elifesciences.org/articles/03638

Internet

https://elifesciences.org/articles/03638

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