The Commonalities and Differences in Mitochondrial Dysfunction Between ex vivo and in vivo Myocardial Global Ischemia Rat Heart Models: Implications for Donation After Circulatory Death Research

The Commonalities and Differences in Mitochondrial Dysfunction Between ex vivo and in vivo Myocardial Global Ischemia Rat Heart Models: Implications for Donation After Circulatory Death Research

Heart transplantation is the ultimate treatment option for patients with advanced heart failure. Since hearts from donation after brain death (DBD) donors are limited, donation after circulatory death (DCD) donor hearts could be another source for heart transplantation. DCD process involves ischemia...

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Bibliographic Details
Main Authors: Mohammed Quader, Oluwatoyin Akande, Stefano Toldo, Renee Cholyway, Le Kang, Edward J. Lesnefsky, Qun Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Physiology
Subjects:
circulatory death donors
brain death donors
ischemia
heart transplantation
mitochondria
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00681/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00681/full

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