All PI3Kinase signaling is not mTOR: Dissecting mTOR-dependent and independent signaling pathways in T cells

The mechanistic target of rapamycin (mTOR) is emerging as playing a central role in regulating T cell activation, differentiation, and function. mTOR integrates diverse signals from the immune microenvironment to shape the outcome of T cell receptor (TCR) antigen recognition. Phosphatidylinositol...

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Bibliographic Details
Main Authors: Christopher Jordan Gamper, Jonathan D. Powell
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-10-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00312/full