Vinpocetine Ameliorates Metabolic-Syndrome-Associated Bladder Overactivity in Fructose-Fed Rats by Restoring Succinate-Modulated cAMP Levels and Exerting Anti-Inflammatory Effects in the Bladder Detrusor Muscle

Vinpocetine Ameliorates Metabolic-Syndrome-Associated Bladder Overactivity in Fructose-Fed Rats by Restoring Succinate-Modulated cAMP Levels and Exerting Anti-Inflammatory Effects in the Bladder Detrusor Muscle

Succinate and its receptor, the G protein-coupled receptor 91 (GPR91), have pathological implications in metabolic syndrome (MetS) and its associated bladder dysfunction, particularly in decreasing bladder cAMP levels and promoting proinflammation. Using fructose-fed rats (FFRs), a rat model of MetS...

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Bibliographic Details
Main Authors: Wei-Chia Lee, Hong-Ren Yu, You-Lin Tain, Kay L.H. Wu, Yao-Chi Chuang, Julie Y.H. Chan
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomedicines
Subjects:
fructose
metabolic syndrome
overactive bladder
succinate
vinpocetine
Online Access:https://www.mdpi.com/2227-9059/10/11/2716

Internet

https://www.mdpi.com/2227-9059/10/11/2716

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