PiT2 deficiency prevents increase of bone marrow adipose tissue during skeletal maturation but not in OVX-induced osteoporosis

PiT2 deficiency prevents increase of bone marrow adipose tissue during skeletal maturation but not in OVX-induced osteoporosis

The common cellular origin between bone marrow adipocytes (BMAds) and osteoblasts contributes to the intimate link between bone marrow adipose tissue (BMAT) and skeletal health. An imbalance between the differentiation ability of BMSCs towards one of the two lineages occurs in conditions like aging...

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Bibliographic Details
Main Authors: Giulia Frangi, Marie Guicheteau, Frederic Jacquot, Grzegorz Pyka, Greet Kerckhofs, Magalie Feyeux, Joëlle Veziers, Pierre Guihard, Boris Halgand, Sophie Sourice, Jérôme Guicheux, Xavier Prieur, Laurent Beck, Sarah Beck-Cormier
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Endocrinology
Subjects:
PiT2/Slc20a2
adipocytes
bone
post-menopausal osteoporotic mouse model
marrow
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.921073/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.921073/full

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