Evaluating the Cysteine-Rich and Catalytic Subdomains of Human Tyrosinase and OCA1-Related Mutants Using 1 μs Molecular Dynamics Simulation

Evaluating the Cysteine-Rich and Catalytic Subdomains of Human Tyrosinase and OCA1-Related Mutants Using 1 μs Molecular Dynamics Simulation

The inherited disorder oculocutaneous albinism type 1 (OCA1) is caused by mutations in the <i>TYR</i> gene encoding tyrosinase (Tyr), an enzyme essential to producing pigments throughout the human body. The intramelanosomal domain of Tyr consists of the cysteine-rich and tyrosinase catal...

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Bibliographic Details
Main Authors: Taariq Woods, Yuri V. Sergeev
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
human tyrosinase
homology model
molecular dynamics simulation of protein urea unfolding
molten globule
cysteine-rich and tyrosinase subdomains
OCA1
Online Access:https://www.mdpi.com/1422-0067/24/17/13032

Internet

https://www.mdpi.com/1422-0067/24/17/13032

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