A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

Cell fate decisions occur through the switch-like, irreversible activation of fate-specifying genes. These activation events are often assumed to be tightly coupled to changes in upstream transcription factors, but could also be constrained by cis-epigenetic mechanisms at individual gene loci. Here,...

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Bibliographic Details
Main Authors: Kenneth KH Ng, Mary A Yui, Arnav Mehta, Sharmayne Siu, Blythe Irwin, Shirley Pease, Satoshi Hirose, Michael B Elowitz, Ellen V Rothenberg, Hao Yuan Kueh
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
stochastic gene expression
epigenetics
gene regulation
lymphocyte development
quantitative and systems biology
Online Access:https://elifesciences.org/articles/37851

Internet

https://elifesciences.org/articles/37851

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