Conformational plasticity of SpyCas9 induced by AcrIIA4 and AcrIIA2: Insights from molecular dynamics simulation

Conformational plasticity of SpyCas9 induced by AcrIIA4 and AcrIIA2: Insights from molecular dynamics simulation

CRISPR-Cas9 systems constitute bacterial adaptive immune systems that protect against phage infections. Bacteriophages encode anti-CRISPR proteins (Acrs) that mitigate the bacterial immune response. However, the structural basis for their inhibitory actions from a molecular perspective remains elusi...

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Bibliographic Details
Main Authors: Shuixiu Wen, Yuxin Zhao, Xinyu Qi, Mingzhu Cai, Kaisheng Huang, Hui Liu, De-Xin Kong
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Computational and Structural Biotechnology Journal
Subjects:
CRISPR-Cas9
AcrIIA4
AcrIIA2
Conformational dynamics
Molecular dynamics simulations
SpyCas9
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023005019

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http://www.sciencedirect.com/science/article/pii/S2001037023005019

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