Synthesis of 6-Amino-5-cyano-1,4-disubstituted-2(1H)-Pyrimidinones via Copper-(I)-catalyzed Alkyne-azide ‘Click Chemistry’ and Their Reactivity

Synthesis of 6-Amino-5-cyano-1,4-disubstituted-2(1H)-Pyrimidinones via Copper-(I)-catalyzed Alkyne-azide ‘Click Chemistry’ and Their Reactivity

In this paper we present the room temperature synthesis of a novel serie of 1,4-disubstituted-1,2,3-triazoles 4a-l by employing the (3 + 2) cycloaddition reaction of pyrimidinones containing alkyne functions with different model azides in the presence of copper sulphate and sodium ascorbate. To obta...

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Bibliographic Details
Main Authors: Fethi Zribi, Romain Duval, Fakher Chabchoub, Françoise Nepveu, Ennaji Najahi, Jan Sudor
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:Molecules
Subjects:
2(1H)-pyrimidinones
1,2,3-triazoles
(3 + 2) cycloaddition
alkynes
azides
Online Access:http://www.mdpi.com/1420-3049/15/12/8841/

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http://www.mdpi.com/1420-3049/15/12/8841/

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