BRAT1 links Integrator and defective RNA processing with neurodegeneration

BRAT1 links Integrator and defective RNA processing with neurodegeneration

Mutations in BRAT1 are associated with neurodevelopmental delay and neurodegeneration. Here, the authors show that BRAT1 is a component of Integrator and is important for processing of specific RNAs. They further demonstrate that BRAT1 mutant patient-derived cells exhibit reduced levels of the Integ...

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Bibliographic Details
Main Authors: Zuzana Cihlarova, Jan Kubovciak, Margarita Sobol, Katerina Krejcikova, Jana Sachova, Michal Kolar, David Stanek, Cyril Barinka, Grace Yoon, Keith W. Caldecott, Hana Hanzlikova
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32763-6

Internet

https://doi.org/10.1038/s41467-022-32763-6

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