The diverse functions of FAT1 in cancer progression: good, bad, or ugly?

Abstract FAT atypical cadherin 1 (FAT1) is among the most frequently mutated genes in many types of cancer. Its highest mutation rate is found in head and neck squamous cell carcinoma (HNSCC), in which FAT1 is the second most frequently mutated gene. Thus, FAT1 has great potential to serve as a targ...

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Bibliographic Details
Main Authors: Zhuo Georgia Chen, Nabil F. Saba, Yong Teng
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Online Access:https://doi.org/10.1186/s13046-022-02461-8