An oviduct-on-a-chip provides an enhanced in vitro environment for zygote genome reprogramming

An oviduct-on-a-chip provides an enhanced in vitro environment for zygote genome reprogramming

In vitro culture has detrimental effects on transcriptomes and epigenetic programming of zygotes. Here the authors use microfluidic technology to co-culture bovine oviduct epithelial cells with zygotes and show that the transcriptomes and global methylation patterns of these zygotes are more similar...

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Bibliographic Details
Main Authors: Marcia A. M. M. Ferraz, Hoon Suk Rho, Daiane Hemerich, Heiko H. W. Henning, Helena T. A. van Tol, Michael Hölker, Urban Besenfelder, Michal Mokry, Peter L. A. M. Vos, Tom A. E. Stout, Séverine Le Gac, Bart M. Gadella
Format: Article
Language:English
Published: Nature Portfolio 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07119-8

Internet

https://doi.org/10.1038/s41467-018-07119-8

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