Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4.

Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4.

We previously established an 80 kb haplotype upstream of TNFSF4 as a susceptibility locus in the autoimmune disease SLE. SLE-associated alleles at this locus are associated with inflammatory disorders, including atherosclerosis and ischaemic stroke. In Europeans, the TNFSF4 causal variants have rema...

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Bibliographic Details
Main Authors: Harinder Manku, Carl D Langefeld, Sandra G Guerra, Talat H Malik, Marta Alarcon-Riquelme, Juan-Manuel Anaya, Sang-Cheol Bae, Susan A Boackle, Elizabeth E Brown, Lindsey A Criswell, Barry I Freedman, Patrick M Gaffney, Peter A Gregersen, Joel M Guthridge, Sang-Hoon Han, John B Harley, Chaim O Jacob, Judith A James, Diane L Kamen, Kenneth M Kaufman, Jennifer A Kelly, Javier Martin, Joan T Merrill, Kathy L Moser, Timothy B Niewold, So-Yeon Park, Bernardo A Pons-Estel, Amr H Sawalha, R Hal Scofield, Nan Shen, Anne M Stevens, Celi Sun, Gary S Gilkeson, Jeff C Edberg, Robert P Kimberly, Swapan K Nath, Betty P Tsao, Tim J Vyse
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3715547?pdf=render

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http://europepmc.org/articles/PMC3715547?pdf=render

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