Mediator complex subunit 1 promotes oral squamous cell carcinoma progression by activating MMP9 transcription and suppressing CD8+ T cell antitumor immunity

Mediator complex subunit 1 promotes oral squamous cell carcinoma progression by activating MMP9 transcription and suppressing CD8+ T cell antitumor immunity

Abstract Background The role of Mediator complex subunit 1 (MED1), a pivotal transcriptional coactivator implicated in diverse biological pathways, remains unexplored in the context of oral squamous cell carcinoma (OSCC). This study aims to elucidate the contributory mechanisms and potential impact...

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Bibliographic Details
Main Authors: Zhe Li, Mengke Sun, Ruimeng Yang, Zheng Wang, Qianyu Zhu, Yue Zhang, Haosun Yang, Zhaosong Meng, Lizhi Hu, Lei Sui
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
The Mediator complex subunit 1
Matrix metalloprotein 9
Transcriptional regulation
Programmed death-ligand 1
Notch signaling pathway
Oral squamous cell carcinoma
Online Access:https://doi.org/10.1186/s13046-024-03191-9

Internet

https://doi.org/10.1186/s13046-024-03191-9

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