Expression of the Platelet-Derived Growth Factor Receptor in Prostate Cancer and Treatment Implications with Tyrosine Kinase Inhibitors

Expression of the Platelet-Derived Growth Factor Receptor in Prostate Cancer and Treatment Implications with Tyrosine Kinase Inhibitors

The platelet-derived growth factor receptor (PDGFR) is a receptor tyrosine kinase overexpressed in a subset of solid tumors and therefore is the target of drugs inhibiting this function such as imatinib mesylate (Gleevec). Thus far, drug therapy has played a limited role in the treatment of localize...

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Bibliographic Details
Main Authors: Matthias D. Hofer, Alice Fecko, Ronglai Shen, Sunita R. Setlur, Kenneth G. Pienta, Scott A. Tomlins, Arul M. Chinnaiyan, Mark A. Rubin
Format: Article
Language:English
Published: Elsevier 2004-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Platelet-derived growth factor receptor (PDGFR)
prostate cancer
imatinib mesylate
tissue microarray
cDNA expression
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558604800277

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http://www.sciencedirect.com/science/article/pii/S1476558604800277

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