Inhibition of Uterine Contractility by Thalidomide Analogs via Phosphodiesterase-4 Inhibition and Calcium Entry Blockade

Inhibition of Uterine Contractility by Thalidomide Analogs via Phosphodiesterase-4 Inhibition and Calcium Entry Blockade

Uterine relaxation is crucial during preterm labor. Phosphodiesterase-4 (PDE-4) inhibitors have been proposed as tocolytics. Some thalidomide analogs are PDE-4 inhibitors. The aim of this study was to assess the uterus-relaxant properties of two thalidomide analogs, methyl 3-(4-nitrophthalimido)-3-...

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Bibliographic Details
Main Authors: Eduardo Fernández-Martínez, Héctor Ponce-Monter, Luis E. Soria-Jasso, Mario I. Ortiz, José-Antonio Arias-Montaño, Guillermo Barragán-Ramírez, Cynthia Mayén-García
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:Molecules
Subjects:
calcium blockers
cAMP
human myometrium
phosphodiesterase-4
preterm labor
relaxation
tocolytics
thalidomide analogs
Online Access:http://www.mdpi.com/1420-3049/21/10/1332

Internet

http://www.mdpi.com/1420-3049/21/10/1332

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