HTAD: a human-in-the-loop framework for supervised chromatin domain detection
Abstract Topologically associating domains (TADs) are essential units of genome architecture, influencing transcriptional regulation and diseases. Despite numerous methods proposed for TAD identification, it remains challenging due to complex background and nested TAD structures. We introduce HTAD,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-12-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-024-03445-x |