High-efficiency purification of divergent AAV serotypes using AAVX affinity chromatography

High-efficiency purification of divergent AAV serotypes using AAVX affinity chromatography

The adeno-associated viral vector (AAV) provides a safe and efficient gene therapy platform with several approved products that have marked therapeutic impact for patients. However, a major bottleneck in the development and commercialization of AAV remains the efficiency, cost, and scalability of AA...

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Bibliographic Details
Main Authors: Michael Florea, Fotini Nicolaou, Simon Pacouret, Eric M. Zinn, Julio Sanmiguel, Eva Andres-Mateos, Carmen Unzu, Amy J. Wagers, Luk H. Vandenberghe
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
gene therapy
adeno-associated
purification
manufacturing
downstream
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122001826

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http://www.sciencedirect.com/science/article/pii/S2329050122001826

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