L'extrait aqueux lyophilisé de Portulaca oleracea prévient contre la peroxydation lipidique en augmentant l'activité de la paraoxonase-1 sérique, chez des rats soumis à un régime enrichi en cholestérol [Aqueous extract of Portulaca oleracea prevents lipid peroxidation and increases serum paraoxonase-1 activity, in rats fed cholesterol enriched-diet]
Introduction. Many studies have shown the effect of medicinal plants on the reduction of lipids and their peroxidation, and on the increase of paraoxonase-1 (PON-1) activity, in hypercholesterolemic rat. Objective. The aim of this study was to determine the effect of aqueous extract of Portulaca ol...
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| Format: | Article |
| Language: | English |
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Société Algérienne de Nutrition
2016-12-01
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| Series: | Nutrition & Santé |
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| Online Access: | http://www.nutrition-sante.dz/articles/l-extrait-aqueux-lyophilise-de-portulaca-oleracea-previent-contre-la-peroxydation-lipidique-en-augmentant-l-activite-de-la-paraoxonase-1-serique-chez-des-rats-soumis-a-un-regime-enrichi-en-cholesterol-yahiaoui-zidan-sherazede-bouderbala-m-bouchenak |
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| author | Yahiaoui ZIDAN Sherazede BOUDERBALA Malika BOUCHENAK |
| author_facet | Yahiaoui ZIDAN Sherazede BOUDERBALA Malika BOUCHENAK |
| author_sort | Yahiaoui ZIDAN |
| collection | DOAJ |
| description | Introduction. Many studies have shown the effect of medicinal plants on the reduction of lipids and their peroxidation, and on the increase of paraoxonase-1 (PON-1) activity, in hypercholesterolemic rat. Objective. The aim of this study was to
determine the effect of aqueous extract of Portulaca oleracea (Po) on serum and lipoproteins lipid peroxidation as well as serum PON-1 activity, in hypercholesterolemic rats. Material and methods. Male Wistar rats (n=12) were fed on 1% cholesterol-
enriched diet for 10 days. After this adaptation phase, hypercholesterolemic rats (total cholesterol (TC) = 5.66±1.60 mmol/L) were divided into two groups submitted to the same diet and treated or not with Po for 28 days. Results. Hypercholesterolemic rats treated with Po were compared to untreated hypercholesterolemic rats. Serum TC, VLDL-C and LDL-HDL1-C were decreased respectively by 45%, 42% and 58%. HDL-C (HDL2 + HDL3) was increased by 34%, in Po-HC group. Lipid peroxidation evaluation showed decreased thiobarbituric acid reactive substances concentrations in serum (-16%), VLDL (-48%), LDL-HDL1 (-32%), HDL2 (-16%) and HDL3 (-41%). Serum PON-1 activity was 1.9-fold higher, in treated than untreated
hypercholesterolemic groups. Conclusion. In hypercholesterolemic rat, it appears that treatment with Po aqueous extract induces hypocholesterolemic effect. Po reduces lipid peroxidation in serum and lipoproteins by increasing serum PON-1 activity. |
| first_indexed | 2024-12-12T09:08:25Z |
| format | Article |
| id | doaj.art-b21e8a3d608b430a843da9c8f890d972 |
| institution | Directory Open Access Journal |
| issn | 2253-0983 2353-026X |
| language | English |
| last_indexed | 2024-12-12T09:08:25Z |
| publishDate | 2016-12-01 |
| publisher | Société Algérienne de Nutrition |
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| series | Nutrition & Santé |
| spelling | doaj.art-b21e8a3d608b430a843da9c8f890d9722022-12-22T00:29:36ZengSociété Algérienne de NutritionNutrition & Santé2253-09832353-026X2016-12-010502107114L'extrait aqueux lyophilisé de Portulaca oleracea prévient contre la peroxydation lipidique en augmentant l'activité de la paraoxonase-1 sérique, chez des rats soumis à un régime enrichi en cholestérol [Aqueous extract of Portulaca oleracea prevents lipid peroxidation and increases serum paraoxonase-1 activity, in rats fed cholesterol enriched-diet]Yahiaoui ZIDAN0Sherazede BOUDERBALA1Malika BOUCHENAK2Laboratoire de Nutrition Clinique et Métabolique, Département de Biologie, Faculté des Sciences de la Nature et de la Vie, Université d'Oran 1 Ahmed Ben Bella, BP 1524 El M'Naouer 31000, Oran, Algérie.Laboratoire de Nutrition Clinique et Métabolique, Département de Biologie, Faculté des Sciences de la Nature et de la Vie, Université d'Oran 1 Ahmed Ben Bella, BP 1524 El M'Naouer 31000, Oran, Algérie.Laboratoire de Nutrition Clinique et Métabolique, Département de Biologie, Faculté des Sciences de la Nature et de la Vie, Université d'Oran 1 Ahmed Ben Bella, BP 1524 El M'Naouer 31000, Oran, Algérie.Introduction. Many studies have shown the effect of medicinal plants on the reduction of lipids and their peroxidation, and on the increase of paraoxonase-1 (PON-1) activity, in hypercholesterolemic rat. Objective. The aim of this study was to determine the effect of aqueous extract of Portulaca oleracea (Po) on serum and lipoproteins lipid peroxidation as well as serum PON-1 activity, in hypercholesterolemic rats. Material and methods. Male Wistar rats (n=12) were fed on 1% cholesterol- enriched diet for 10 days. After this adaptation phase, hypercholesterolemic rats (total cholesterol (TC) = 5.66±1.60 mmol/L) were divided into two groups submitted to the same diet and treated or not with Po for 28 days. Results. Hypercholesterolemic rats treated with Po were compared to untreated hypercholesterolemic rats. Serum TC, VLDL-C and LDL-HDL1-C were decreased respectively by 45%, 42% and 58%. HDL-C (HDL2 + HDL3) was increased by 34%, in Po-HC group. Lipid peroxidation evaluation showed decreased thiobarbituric acid reactive substances concentrations in serum (-16%), VLDL (-48%), LDL-HDL1 (-32%), HDL2 (-16%) and HDL3 (-41%). Serum PON-1 activity was 1.9-fold higher, in treated than untreated hypercholesterolemic groups. Conclusion. In hypercholesterolemic rat, it appears that treatment with Po aqueous extract induces hypocholesterolemic effect. Po reduces lipid peroxidation in serum and lipoproteins by increasing serum PON-1 activity.http://www.nutrition-sante.dz/articles/l-extrait-aqueux-lyophilise-de-portulaca-oleracea-previent-contre-la-peroxydation-lipidique-en-augmentant-l-activite-de-la-paraoxonase-1-serique-chez-des-rats-soumis-a-un-regime-enrichi-en-cholesterol-yahiaoui-zidan-sherazede-bouderbala-m-bouchenakRatPortulaca oleraceaCholesterolemiaLipoproteinsTBARSParaoxonase-1 |
| spellingShingle | Yahiaoui ZIDAN Sherazede BOUDERBALA Malika BOUCHENAK L'extrait aqueux lyophilisé de Portulaca oleracea prévient contre la peroxydation lipidique en augmentant l'activité de la paraoxonase-1 sérique, chez des rats soumis à un régime enrichi en cholestérol [Aqueous extract of Portulaca oleracea prevents lipid peroxidation and increases serum paraoxonase-1 activity, in rats fed cholesterol enriched-diet] Nutrition & Santé Rat Portulaca oleracea Cholesterolemia Lipoproteins TBARS Paraoxonase-1 |
| title | L'extrait aqueux lyophilisé de Portulaca oleracea prévient contre la peroxydation lipidique en augmentant l'activité de la paraoxonase-1 sérique, chez des rats soumis à un régime enrichi en cholestérol [Aqueous extract of Portulaca oleracea prevents lipid peroxidation and increases serum paraoxonase-1 activity, in rats fed cholesterol enriched-diet] |
| title_full | L'extrait aqueux lyophilisé de Portulaca oleracea prévient contre la peroxydation lipidique en augmentant l'activité de la paraoxonase-1 sérique, chez des rats soumis à un régime enrichi en cholestérol [Aqueous extract of Portulaca oleracea prevents lipid peroxidation and increases serum paraoxonase-1 activity, in rats fed cholesterol enriched-diet] |
| title_fullStr | L'extrait aqueux lyophilisé de Portulaca oleracea prévient contre la peroxydation lipidique en augmentant l'activité de la paraoxonase-1 sérique, chez des rats soumis à un régime enrichi en cholestérol [Aqueous extract of Portulaca oleracea prevents lipid peroxidation and increases serum paraoxonase-1 activity, in rats fed cholesterol enriched-diet] |
| title_full_unstemmed | L'extrait aqueux lyophilisé de Portulaca oleracea prévient contre la peroxydation lipidique en augmentant l'activité de la paraoxonase-1 sérique, chez des rats soumis à un régime enrichi en cholestérol [Aqueous extract of Portulaca oleracea prevents lipid peroxidation and increases serum paraoxonase-1 activity, in rats fed cholesterol enriched-diet] |
| title_short | L'extrait aqueux lyophilisé de Portulaca oleracea prévient contre la peroxydation lipidique en augmentant l'activité de la paraoxonase-1 sérique, chez des rats soumis à un régime enrichi en cholestérol [Aqueous extract of Portulaca oleracea prevents lipid peroxidation and increases serum paraoxonase-1 activity, in rats fed cholesterol enriched-diet] |
| title_sort | l extrait aqueux lyophilise de portulaca oleracea previent contre la peroxydation lipidique en augmentant l activite de la paraoxonase 1 serique chez des rats soumis a un regime enrichi en cholesterol aqueous extract of portulaca oleracea prevents lipid peroxidation and increases serum paraoxonase 1 activity in rats fed cholesterol enriched diet |
| topic | Rat Portulaca oleracea Cholesterolemia Lipoproteins TBARS Paraoxonase-1 |
| url | http://www.nutrition-sante.dz/articles/l-extrait-aqueux-lyophilise-de-portulaca-oleracea-previent-contre-la-peroxydation-lipidique-en-augmentant-l-activite-de-la-paraoxonase-1-serique-chez-des-rats-soumis-a-un-regime-enrichi-en-cholesterol-yahiaoui-zidan-sherazede-bouderbala-m-bouchenak |
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