Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation

Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation

The discovery of multi-targeting ligands of bacterial enzymes is an important strategy to combat rapidly spreading antimicrobial resistance. Bacterial DNA gyrase and topoisomerase IV are validated targets for the development of antibiotics. They can be inhibited at their catalytic sites or at their...

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Bibliographic Details
Main Authors: Martina Durcik, Žiga Skok, Janez Ilaš, Nace Zidar, Anamarija Zega, Petra Éva Szili, Gábor Draskovits, Tamás Révész, Danijel Kikelj, Akos Nyerges, Csaba Pál, Lucija Peterlin Mašič, Tihomir Tomašič
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Pharmaceutics
Subjects:
antibacterial
ciprofloxacin
DNA gyrase
dual inhibitor
hybrid
Online Access:https://www.mdpi.com/1999-4923/13/1/6

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https://www.mdpi.com/1999-4923/13/1/6

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