A Novel Patient-Specific Human Cardiovascular System Phantom (HCSP) for Reconstructions of Pulsatile Blood Hemodynamic Inside Abdominal Aortic Aneurysm

Background and objectives: Post-operative complications of endovascular aneurysm repair, such as endoleaks, migration, or angular bands in a stent-graft or narrowing and occlusion of a stent-graft lumen are potentially life-threatening and difficult to perceive without constant monitoring. Therefore...

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Main Authors: Andrzej Polanczyk, Michal Podgorski, Maciej Polanczyk, Aleksandra Piechota-Polanczyk, Christoph Neumayer, Ludomir Stefanczyk
Format: Article
Language:English
Published: IEEE 2018-01-01
Series:IEEE Access
Subjects:
Online Access:https://ieeexplore.ieee.org/document/8493465/
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author Andrzej Polanczyk
Michal Podgorski
Maciej Polanczyk
Aleksandra Piechota-Polanczyk
Christoph Neumayer
Ludomir Stefanczyk
author_facet Andrzej Polanczyk
Michal Podgorski
Maciej Polanczyk
Aleksandra Piechota-Polanczyk
Christoph Neumayer
Ludomir Stefanczyk
author_sort Andrzej Polanczyk
collection DOAJ
description Background and objectives: Post-operative complications of endovascular aneurysm repair, such as endoleaks, migration, or angular bands in a stent-graft or narrowing and occlusion of a stent-graft lumen are potentially life-threatening and difficult to perceive without constant monitoring. Therefore, our work aimed to propose a new ex-vivo system called Human-Cardiovascular-System-Phantom (HCSP) to simulate pulsatile hemodynamic in the abdominal aortic aneurysm (AAA) before and after stent-graft placement. Materials and Methods: To verify the system twelve AAA-models, before and after medical treatment, were reconstructed based on medical data from AngioCT and US-Doppler. Furthermore, the 3D printed models were installed in the HCSP to reconstruct pulsatile flow and mechanical behavior of the aortic aneurysm wall which was tracked with DC. Clinical data, including results from 2D-Speckle-tracking-technique (2DSTT), were also used to verify wall deformation for heart rate ranging between 60 to 120 min<sup>-1</sup>, and were confronted with results on wall deformation measured with DC in 3D printed aneurysms. Results: HCSP was able to track and calculate wall deformation with accuracy from 94.4% to 100% compared to 2DSTT. Wall deformation calculated with DC did not statistically vary from 2DSTT values. For instance, wall deformation measured with 2DSTT for anterior position and for 70 min<sup>-1</sup> was equal to 4.18&#x00B1;0.05 mm, 3.70&#x00B1;0.08 mm and 2.00&#x00B1;0.08 mm for AAA, AAA+thrombus and AAA+stent-graft, respectively. Those values were comparable with those measured with DC. Conclusions: The proposed HCSP allows to successfully follow hemodynamic changes in the AAA-model with thrombus or stent-graft and under different hemodynamic conditions. Thus, our approach may be useful in monitoring the influence of a stent-graft's spatial configuration on different hemodynamic parameters inside the AAA in the laboratory conditions.
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spelling doaj.art-b222d13f63b04b19bf3924ff24aee58f2022-12-21T23:03:13ZengIEEEIEEE Access2169-35362018-01-016618966190310.1109/ACCESS.2018.28763778493465A Novel Patient-Specific Human Cardiovascular System Phantom (HCSP) for Reconstructions of Pulsatile Blood Hemodynamic Inside Abdominal Aortic AneurysmAndrzej Polanczyk0https://orcid.org/0000-0001-8894-752XMichal Podgorski1Maciej Polanczyk2Aleksandra Piechota-Polanczyk3Christoph Neumayer4Ludomir Stefanczyk5Department of Heat and Mass Transfer, Faculty of Process and Environmental Engineering, Lodz University of Technology, Lodz, PolandDepartment of Radiology and Diagnostic Imaging, Medical University of Lodz, Lodz, PolandDepartment of Surgery, Division of Vascular Surgery, Medical University of Vienna, Vienna, AustriaDepartment of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, PolandDepartment of Heat and Mass Transfer, Faculty of Process and Environmental Engineering, Lodz University of Technology, Lodz, PolandDepartment of Radiology and Diagnostic Imaging, Medical University of Lodz, Lodz, PolandBackground and objectives: Post-operative complications of endovascular aneurysm repair, such as endoleaks, migration, or angular bands in a stent-graft or narrowing and occlusion of a stent-graft lumen are potentially life-threatening and difficult to perceive without constant monitoring. Therefore, our work aimed to propose a new ex-vivo system called Human-Cardiovascular-System-Phantom (HCSP) to simulate pulsatile hemodynamic in the abdominal aortic aneurysm (AAA) before and after stent-graft placement. Materials and Methods: To verify the system twelve AAA-models, before and after medical treatment, were reconstructed based on medical data from AngioCT and US-Doppler. Furthermore, the 3D printed models were installed in the HCSP to reconstruct pulsatile flow and mechanical behavior of the aortic aneurysm wall which was tracked with DC. Clinical data, including results from 2D-Speckle-tracking-technique (2DSTT), were also used to verify wall deformation for heart rate ranging between 60 to 120 min<sup>-1</sup>, and were confronted with results on wall deformation measured with DC in 3D printed aneurysms. Results: HCSP was able to track and calculate wall deformation with accuracy from 94.4% to 100% compared to 2DSTT. Wall deformation calculated with DC did not statistically vary from 2DSTT values. For instance, wall deformation measured with 2DSTT for anterior position and for 70 min<sup>-1</sup> was equal to 4.18&#x00B1;0.05 mm, 3.70&#x00B1;0.08 mm and 2.00&#x00B1;0.08 mm for AAA, AAA+thrombus and AAA+stent-graft, respectively. Those values were comparable with those measured with DC. Conclusions: The proposed HCSP allows to successfully follow hemodynamic changes in the AAA-model with thrombus or stent-graft and under different hemodynamic conditions. Thus, our approach may be useful in monitoring the influence of a stent-graft's spatial configuration on different hemodynamic parameters inside the AAA in the laboratory conditions.https://ieeexplore.ieee.org/document/8493465/Implantsstress controlstress measurementstructural shapessurgical instrumentsthrombosis
spellingShingle Andrzej Polanczyk
Michal Podgorski
Maciej Polanczyk
Aleksandra Piechota-Polanczyk
Christoph Neumayer
Ludomir Stefanczyk
A Novel Patient-Specific Human Cardiovascular System Phantom (HCSP) for Reconstructions of Pulsatile Blood Hemodynamic Inside Abdominal Aortic Aneurysm
IEEE Access
Implants
stress control
stress measurement
structural shapes
surgical instruments
thrombosis
title A Novel Patient-Specific Human Cardiovascular System Phantom (HCSP) for Reconstructions of Pulsatile Blood Hemodynamic Inside Abdominal Aortic Aneurysm
title_full A Novel Patient-Specific Human Cardiovascular System Phantom (HCSP) for Reconstructions of Pulsatile Blood Hemodynamic Inside Abdominal Aortic Aneurysm
title_fullStr A Novel Patient-Specific Human Cardiovascular System Phantom (HCSP) for Reconstructions of Pulsatile Blood Hemodynamic Inside Abdominal Aortic Aneurysm
title_full_unstemmed A Novel Patient-Specific Human Cardiovascular System Phantom (HCSP) for Reconstructions of Pulsatile Blood Hemodynamic Inside Abdominal Aortic Aneurysm
title_short A Novel Patient-Specific Human Cardiovascular System Phantom (HCSP) for Reconstructions of Pulsatile Blood Hemodynamic Inside Abdominal Aortic Aneurysm
title_sort novel patient specific human cardiovascular system phantom hcsp for reconstructions of pulsatile blood hemodynamic inside abdominal aortic aneurysm
topic Implants
stress control
stress measurement
structural shapes
surgical instruments
thrombosis
url https://ieeexplore.ieee.org/document/8493465/
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