MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma

MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma

Hypoxia is an important tumor feature and hypoxia-inducible factor 1 (HIF-1) is a master regulator of cell response to hypoxia. Mouse double minute 2 homolog (MDM2) promotes cancer cell survival in retinoblastoma (RB), with the underlying mechanism remaining elusive. In this study, we investigated t...

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Bibliographic Details
Main Authors: Shouhua Zhang, Hongyan Xu, Weiming Li, Jianfeng Ji, Qifang Jin, Leifeng Chen, Qiang Gan, Qiang Tao, Yong Chai
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Pathology and Oncology Research
Subjects:
HIF-1α
retinoblastoma
MDM2
pVHL
hypoxia
Online Access:https://www.por-journal.com/articles/10.3389/pore.2023.1610801/full

Internet

https://www.por-journal.com/articles/10.3389/pore.2023.1610801/full

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