Chromenone-based GSK-3β inhibitors as potential therapeutic targets for cardiovascular diseases: In silico study, molecular dynamics, and ADMET profiles

Chromenone-based GSK-3β inhibitors as potential therapeutic targets for cardiovascular diseases: In silico study, molecular dynamics, and ADMET profiles

Glycogen synthase kinase-3 beta (GSK-3β) regulates glycogen metabolism and many different cellulars, including apoptosis, signaling, and neural. It is a crucial therapeutic receptor in heart disease, type 2 diabetes, and Alzheimer's. In this study, using computational methods, flavonoid compoun...

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Bibliographic Details
Main Authors: Min Zhang, San Zhou, Noor H. Obaid, Usama S. Altimari, Mohanad Adel Mohammed, Ahmed Kareem Obaid Aldulaim, Emad Salaam Abood, Hossam Kotb, Ayesheh Enayati, Vahid Khori, Hassan Mirzaei, Aref Salehi, Alireza Soltani, Mohd Sani Sarjadi, Md. Lutfor Rahman
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Arabian Journal of Chemistry
Subjects:
GSK-3β
Chromenone
Virtual screening
Molecular dynamics simulation
ADMET
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535222006049

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http://www.sciencedirect.com/science/article/pii/S1878535222006049

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