Peripheral blood mononuclear cells exhibit increased mitochondrial respiration after adjuvant chemo‐ and radiotherapy for early breast cancer

Peripheral blood mononuclear cells exhibit increased mitochondrial respiration after adjuvant chemo‐ and radiotherapy for early breast cancer

Abstract Background Adjuvant chemo‐ and radiotherapy cause cellular damage to tumorous and healthy dividing cells. Chemotherapy has been shown to cause mitochondrial respiratory dysfunction in non‐tumorous tissues, but the effects on human peripheral blood mononuclear cells (PBMCs) remain unknown. A...

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Bibliographic Details
Main Authors: Ida Bager Christensen, Marie‐Louise Abrahamsen, Lucas Ribas, Kristian Buch‐Larsen, Djordje Marina, Michael Andersson, Steen Larsen, Peter Schwarz, Flemming Dela, Linn Gillberg
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Cancer Medicine
Subjects:
breast cancer
chemotherapy
energy metabolism
high‐resolution respirometry
mitochondria
peripheral blood mononuclear cells
Online Access:https://doi.org/10.1002/cam4.6333

Internet

https://doi.org/10.1002/cam4.6333

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