Prioritization of risk genes for Alzheimer’s disease: an analysis framework using spatial and temporal gene expression data in the human brain based on support vector machine

Background: Alzheimer’s disease (AD) is a complex disorder, and its risk is influenced by multiple genetic and environmental factors. In this study, an AD risk gene prediction framework based on spatial and temporal features of gene expression data (STGE) was proposed.Methods: We proposed an AD risk...

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Bibliographic Details
Main Authors: Shiyu Wang, Xixian Fang, Xiang Wen, Congying Yang, Ying Yang, Tianxiao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1190863/full