Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy

Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy

Abstract Hyperactivated ribosome biosynthesis is attributed to a need for elevated protein synthesis that accommodates cell growth and division, and is characterized by nucleomorphometric alterations and increased nucleolar counts. Ribosome biogenesis is challenged when DNA-damaging treatments such...

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Bibliographic Details
Main Authors: Brandon J. Metge, Heba A. Alsheikh, Dongquan Chen, Amr R. Elhamamsy, Dominique C. Hinshaw, Bo-Ruei Chen, Barry P. Sleckman, Rajeev S. Samant, Lalita A. Shevde
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-023-00410-y

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https://doi.org/10.1038/s41698-023-00410-y

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