Protein-Mediated Carotenoid Delivery Suppresses the Photoinducible Oxidation of Lipofuscin in Retinal Pigment Epithelial Cells

Protein-Mediated Carotenoid Delivery Suppresses the Photoinducible Oxidation of Lipofuscin in Retinal Pigment Epithelial Cells

Lipofuscin of retinal pigment epithelium (RPE) cells is a complex heterogeneous system of chromophores which accumulates as granules during the cell’s lifespan. Lipofuscin serves as a source of various cytotoxic effects linked with oxidative stress. Several age-related eye diseases such as macular d...

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Bibliographic Details
Main Authors: Alexey N. Semenov, Eugene G. Maksimov, Anastasia M. Moysenovich, Marina A. Yakovleva, Georgy V. Tsoraev, Alla A. Ramonova, Evgeny A. Shirshin, Nikolai N. Sluchanko, Tatiana B. Feldman, Andrew B. Rubin, Mikhail P. Kirpichnikov, Mikhail A. Ostrovsky
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Antioxidants
Subjects:
carotenoid-binding protein
zeaxanthin delivery
retinal pigment epithelium
lipofuscin
bisretinoid fluorophores
bisretinoid oxidation and degradation products
Online Access:https://www.mdpi.com/2076-3921/12/2/413

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https://www.mdpi.com/2076-3921/12/2/413

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