Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2

Senescent cells have long been associated with deleterious effects in aging-related pathologies, although recent studies have uncovered their beneficial roles in certain contexts, such as wound healing. We have found that hepatic stellate cells (HSCs) underwent senescence within 2 days after 2/3 par...

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Bibliographic Details
Main Authors: Naiyuan Cheng, Ki-Hyun Kim, Lester F. Lau
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-07-01
Series:JCI Insight
Subjects:
Online Access:https://doi.org/10.1172/jci.insight.158207