Sulforaphane suppresses the activity of sterol regulatory element-binding proteins (SREBPs) by promoting SREBP precursor degradation

Sulforaphane suppresses the activity of sterol regulatory element-binding proteins (SREBPs) by promoting SREBP precursor degradation

Abstract Sterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate various genes involved in cholesterol and fatty acid synthesis. In this study, we describe that naturally occurring isothiocyanate sulforaphane (SFaN) impairs fatty acid synthase promoter activity an...

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Bibliographic Details
Main Authors: Shingo Miyata, Manami Kodaka, Akito Kikuchi, Yuki Matsunaga, Kenta Shoji, Yen-Chou Kuan, Masamori Iwase, Keita Takeda, Ryo Katsuta, Ken Ishigami, Yu Matsumoto, Tsukasa Suzuki, Yuji Yamamoto, Ryuichiro Sato, Jun Inoue
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-12347-6

Internet

https://doi.org/10.1038/s41598-022-12347-6

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