Formononetin isolated from Sophorae flavescentis inhibits B cell-IgE production by regulating ER-stress transcription factor XBP-1

Formononetin isolated from Sophorae flavescentis inhibits B cell-IgE production by regulating ER-stress transcription factor XBP-1

RationaleIgE plays an important pathologic role in most, if not all, allergic conditions. We previously showed that ASHMI (anti-asthma herbal medicine intervention) suppressed IgE production in murine models of asthma and in asthma subjects. However, the active compounds in ASHMI responsible for the...

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Bibliographic Details
Main Authors: Nan Yang, Ibrahim Musa, Anish R. Maskey, Ke Li, Zhenzhen Wang, Banghao Liang, Shuwei Zhang, Jixun Zhan, Xiu-Min Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Allergy
Subjects:
asthma
antiasthma simplified herbal medicine intervention (ASHMI)
formononetin
IgE inhibition
IgE heavy chain
XBP-1
Online Access:https://www.frontiersin.org/articles/10.3389/falgy.2022.1056203/full

Internet

https://www.frontiersin.org/articles/10.3389/falgy.2022.1056203/full

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