Calpain-Independent Intracellular Protease Activity Is Elevated in Excitotoxic Cortical Neurons Prior to Delayed Calcium Deregulation and Mitochondrial Dysfunction

Calpain-Independent Intracellular Protease Activity Is Elevated in Excitotoxic Cortical Neurons Prior to Delayed Calcium Deregulation and Mitochondrial Dysfunction

Glutamate excitotoxicity contributes to many neurodegenerative diseases. Excessive glutamate receptor-mediated calcium entry causes delayed calcium deregulation (DCD) that coincides with abrupt mitochondrial depolarization. We developed cA-TAT, a live-cell protease activity reporter based on a vimen...

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Bibliographic Details
Main Authors: Brian M. Polster, Karla A. Mark, Rafael Arze, Derek Hudson
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomolecules
Subjects:
calpain
glutamate
NMDA
excitotoxicity
proteasome
mitochondria
Online Access:https://www.mdpi.com/2218-273X/12/7/1004

Internet

https://www.mdpi.com/2218-273X/12/7/1004

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