Novel phenolic inhibitors of small/intermediate-conductance Ca²⁺-activated K⁺ channels, KCa3.1 and KCa2.3.

Novel phenolic inhibitors of small/intermediate-conductance Ca²⁺-activated K⁺ channels, KCa3.1 and KCa2.3.

KCa3.1 channels are calcium/calmodulin-regulated voltage-independent K(+) channels that produce membrane hyperpolarization and shape Ca(2+)-signaling and thereby physiological functions in epithelia, blood vessels, and white and red blood cells. Up-regulation of KCa3.1 is evident in fibrotic and inf...

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Bibliographic Details
Main Authors: Aida Oliván-Viguera, Marta Sofía Valero, María Divina Murillo, Heike Wulff, Angel-Luis García-Otín, José-Miguel Arbonés-Mainar, Ralf Köhler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3597730?pdf=render

Internet

http://europepmc.org/articles/PMC3597730?pdf=render

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