Multiple Fra-1-bound enhancers showing different molecular and functional features can cooperate to repress gene transcription

Abstract Background How transcription factors (TFs) down-regulate gene expression remains ill-understood, especially when they bind to multiple enhancers contacting the same gene promoter. In particular, it is not known whether they exert similar or significantly different molecular effects at these...

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Bibliographic Details
Main Authors: Fabienne Bejjani, Emilie Evanno, Samantha Mahfoud, Claire Tolza, Kazem Zibara, Marc Piechaczyk, Isabelle Jariel-Encontre
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Cell & Bioscience
Subjects:
Online Access:https://doi.org/10.1186/s13578-023-01077-5