Amyloid Precursor Protein Changes Arrangement in a Membrane and Its Structure Depending on the Cholesterol Content

Amyloid Precursor Protein Changes Arrangement in a Membrane and Its Structure Depending on the Cholesterol Content

One of the hallmarks of Alzheimer’s disease (AD) is the accumulation of amyloid beta (Aβ) peptides in the brain. The processing of amyloid precursor protein (APP) into Aβ is dependent on the location of APP in the membrane, membrane lipid composition and, possibly, presence of lipid rafts. In this s...

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Bibliographic Details
Main Authors: Vladimir D. Krasnobaev, Yaroslav V. Bershatsky, Olga V. Bocharova, Eduard V. Bocharov, Oleg V. Batishchev
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Membranes
Subjects:
Alzheimer’s disease (AD)
amyloid precursor protein (APP)
atomic force microscopy (AFM)
amyloidogenic mutant L723P
amyloid beta (Aβ) peptides
lipid raft
Online Access:https://www.mdpi.com/2077-0375/13/8/706

Internet

https://www.mdpi.com/2077-0375/13/8/706

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