Enhanced CXCR4 Expression Associates with Increased Gene Body 5-Hydroxymethylcytosine Modification but not Decreased Promoter Methylation in Colorectal Cancer

Enhanced CXCR4 Expression Associates with Increased Gene Body 5-Hydroxymethylcytosine Modification but not Decreased Promoter Methylation in Colorectal Cancer

In colorectal cancer (CRC), upregulation of the C-X-C motif chemokine receptor 4 (CXCR4) is correlated with metastasis and poor prognosis, highlighting the need to further elucidate <i>CXCR4</i>&#8217;s regulation in CRC. For the first time, DNA methylation and 5-hydroxymethylcytosin...

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Bibliographic Details
Main Authors: Alexei J. Stuckel, Wei Zhang, Xu Zhang, Shuai Zeng, Urszula Dougherty, Reba Mustafi, Qiong Zhang, Elsa Perreand, Tripti Khare, Trupti Joshi, Diana C. West-Szymanski, Marc Bissonnette, Sharad Khare
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
colorectal cancer
dna methylation
epigenetic regulation
cxcr4 gene expression
5-hydroxymethylcytosine
Online Access:https://www.mdpi.com/2072-6694/12/3/539

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https://www.mdpi.com/2072-6694/12/3/539

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