Directed Evolution Detects Supernumerary Centric Chromosomes Conferring Resistance to Azoles in Candida auris

Directed Evolution Detects Supernumerary Centric Chromosomes Conferring Resistance to Azoles in Candida auris

ABSTRACT Candida auris exhibits resistance to multiple antifungal drug classes and sterilization agents, posing threats to the immunocompromised worldwide. Among the four major geographical clades, the East Asian clade 2 isolates of C. auris are mostly drug susceptible. In this study, we experimenta...

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Bibliographic Details
Main Authors: Aswathy Narayanan, Praveen Kumar, Anshu Chauhan, Mohit Kumar, Kusum Yadav, Atanu Banerjee, Ravi Datta Sharma, Shivaprakash M. Rudramurthy, Arunaloke Chakrabarti, Kaustuv Sanyal, Rajendra Prasad
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:mBio
Subjects:
drug resistance
experimental evolution
extra chromosomes
karyotype
Online Access:https://journals.asm.org/doi/10.1128/mbio.03052-22

Internet

https://journals.asm.org/doi/10.1128/mbio.03052-22

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