The repurposing of Tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug-resistant Shigella spp

The repurposing of Tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug-resistant Shigella spp

Background: Diarrhoea remains one of the leading causes of childhood mortality globally. Recent epidemiological studies conducted in low-middle income countries (LMICs) identified Shigella spp. as the first and second most predominant agent of dysentery and moderate diarrhoea, respectively. Antimicr...

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Bibliographic Details
Main Authors: Elena Fernández Álvaro, Phat Voong Vinh, Cristina de Cozar, David R Willé, Beatriz Urones, Alvaro Cortés, Alan Price, Nhu Tran Do Hoang, Tuyen Ha Thanh, Molly McCloskey, Shareef Shaheen, Denise Dayao, Amanda Martinot, Jaime de Mercado, Pablo Castañeda, Adolfo García-Perez, Benson Singa, Patricia Pavlinac, Judd Walson, Maria Santos Martínez-Martínez, Samuel LM Arnold, Saul Tzipori, Lluis Ballell Pages, Stephen Baker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-03-01
Series:eLife
Subjects:
Shigella spp
drug discovery
multi-drug resistance
dysentery
diarrhoea
carbapenems
Online Access:https://elifesciences.org/articles/69798

Internet

https://elifesciences.org/articles/69798

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