Mechanism of Resistance Development in <i>E. coli</i> against TCAT, a Trimethoprim-Based Photoswitchable Antibiotic

Mechanism of Resistance Development in <i>E. coli</i> against TCAT, a Trimethoprim-Based Photoswitchable Antibiotic

During the last decades, a continuous rise of multi-drug resistant pathogens has threatened antibiotic efficacy. To tackle this key challenge, novel antimicrobial therapies are needed with increased specificity for the site of infection. Photopharmacology could enable such specificity by allowing fo...

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Bibliographic Details
Main Authors: Anna I. Lauxen, Piermichele Kobauri, Michael Wegener, Mickel J. Hansen, Nicole S. Galenkamp, Giovanni Maglia, Wiktor Szymanski, Ben L. Feringa, Oscar P. Kuipers
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceuticals
Subjects:
photoswitchable antibiotic
trimethoprim
TCAT
resistance mechanism
<i>E. coli</i>
TolC
Online Access:https://www.mdpi.com/1424-8247/14/5/392

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https://www.mdpi.com/1424-8247/14/5/392

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